![]() Calcium may also precipitate in the eyes (band keratopathy) and in soft tissues around the joints. Increased plasma calcium may give rise to renal lithiasis or acute pancreatitis. Transient or prolonged hypercalcaemia may exceed the solubility product of calcium and result in tissue damage. Disodium Edetate may be used to temporarily reduce serum Calcium in patients with hypercalcaemia. ![]() As long as significant quantities of lead remain in the bone, any intercurrent illness which causes demineralisation can cause mobilisation of toxic quantities of lead into soft tissues and exacerbate plumbism. Comparing the results of a 12-hour urine collection, pre-EDTA therapy, with the results of a 12-hour urine collection, during/post initial EDTA chelation, should confirm the early excretory surge of lead. Diagnostic laboratory tests include blood lead, hair analysis, urine coproporphyrin, urine delta-aminolevulinic acid, x-ray of abdomen and x-ray of long bones. Chronic lead poisoning causes variable involvement of the Central Nervous System, the blood forming organs and the gastrointestinal tract. Poisoning is manifested by a metallic taste, anorexia, irritability, apathy, abdominal colic, vomiting, diarrhoea, constipation, headache, leg cramps, black stools, oliguria, stupor, convulsions, palsies and coma. Lead poisoning may occur by ingestion or inhalation of lead dust or fumes. There are no recognised safe limits for lead intoxication. For patients with elevated serum calcium or hypermobility of their body pools of calcium where there may be transiently or prolonged raised serum calcium (see "Indications (2)"), the EDTA of choice for removing heavy metals may be Disodium Edetate. ![]() However it must be noted that Disodium Edetate is equally effective with Calcium Disodium Edetate in removing heavy metals, even in the absence of hypercalcaemia. This is especially so where there is a concomitant hypercalcaemic problem (refer "Indications (2)"). Disodium Edetate is particularly effective in treating lead accumulation and lead poisoning. ![]()
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